FDA Soon to Approve New HIV Inhibitor

A new medication soon to be on the market for patients with HIV could make life a little easier. In a new drug class of antiretrovial medications called integrase inhibitors, Isentress is on the fast track with the FDA to be approved for use. Created by Merick, Isentress being the first in its classification is an anti-HIV medicine that helps control HIV infection used in combination of additional antiretrovial agents.
 
Integrase inhibitors are drugs that prevent HIV from using the integrase enzyme to combine its instructions into the CD4 or T-cells instructions. Stopping the use of the integrase enzyme, the integrase inhibitors prevent HIV from creating more of itself, putting the progression of HIV at a halt. Simply put, Isentress works by inhibiting the insertion of HIV-1 DNA into human DNA. Merick's studies have shown that their new drug Isentress used in combination with other antiretrovial medications maintained HIV-1 load suppression and raised T-cell counts over a 48 week period of time in comparison with a placebo during their drug trials.
 
Isentress is made for use by adult HIV patients that have already taken or are currently taking anti-HIV medications and they are not controlling their HIV such as those that are resistant to more than one type of anti-HIV medication. It is still unknown at this time what effect Isentress has on new patients or patients under the age of 16 years of age that have not had the opportunity to start an anti-HIV inhibitor regimen so for now it is only recommended for those that have had treatment and meet the age requirement. 
 
This new drug does not claim to be a cure by any means nor does it reduce the risk of transmitting HIV to others. Isentress has to be used in combination with other anti-HIV inhibitors to work properly. Most HIV patients commonly are prescribed at least three anti-HIV medications to help control the deadly virus. Unknown at this time is long term benefits and side effects of this new inhibitor that shows so much promise. It is strongly recommended that if you do plan to add Isentress to your regular regimen of medications, that you follow up closely with your doctor. In addition to the unknown there is yet to be any study results showing the effect of Isentress on the clinical progression of HIV-1.
 
Major symptoms to look out for while taking Isentress is what is known as immune reconstitution syndrome. This is usually a symptom in patients with advanced HIV (AIDS) infection when the new treatment is started. Signs and symptoms of inflammation from infections may occur while the medications work to control the HIV infection and strengthen the immune system. If you think that you are experiencing any of these symptoms including any infections at all, it is advised that you see your doctor right away. Other side effects of Isentress that are common in most medications is nausea, vomiting, diarrhea and dizziness. They are not a cause for alarm, but if troublesome speak with your doctor for a solution that may fit for you.
 
Official approval by the FDA of the integrase inhibitor Isentress should be in July sometime.

I really need some information of Pitt Bulls.

I am really interested in owning an American Pitt Bull Terrior, and I'm in need of some information about their temperment and how they are with children and other dogs and cats. Any information would be greatly appreciated.

Barn fires - every horse owner's nightmare

Yesterday evening, fifteen horses died in a fire at a boarding stable here in Washington state. Fire investigators are still looking into the cause of the fire. The specter of a barn fire looms over every horse owner - as it should. It's not uncommon for a barn to burn to the ground in the space of a few minutes. In cases where the structure remains intact, horses can die quickly from smoke inhalation. Everyone who works in your barn should be involved in fire prevention. Ignition
  • Cigarette smoking is an obvious source of flame. A lit cigarette accidentally dropped into a pile of loose hay can kick everything off. No smoking in the barn!
  • Piles of dirty rags can spontaneously combust. Rags which have come in contact with any chemical, even something as innocuous as leather conditioner, should always be cleaned before being put back on the shelf. Oily rags are a common culprit in fires, but other chemicals can break down over time and become flammable.
  • Damp hay can spontaneously combust. Horse safety expert Michelle Staples reports that "One of the three major causes of stable fires is hay."
  • Electrical equipment should never be left to run unattended. Stable fires can started by box fans, space heaters, radios - anything that plugs into the wall. If you like to leave a radio on for your horses, buy one that can run on rechargeable batteries.
  • Make sure that your electrical system is up to code, and use it correctly. Don't chain together more than one extension cord per outlet, and don't use an adapter so that you can plug a ton of things into the same outlet. Inspect extension cords frequently, looking for cracks and mouse bites in the insulation.
Prevention
  • Keep loose hay swept up - not only in the hay room, but in the tack room, aisles, and the dozens of other nooks and crannies where the Loose Hay Fairies sprinkle their magic. Loose hay can spread a fire quickly.
  • Keep fire extinguishers beside every exit, inside every room, and at the middle of any long aisle. Make sure that everyone who works in your barn knows the location of every fire extinguisher, and knows how to use them.
  • Make sure your phone is easy to reach, and that everyone knows where it is. If you have a cordless phone, designate a spot for the handset and make sure it doesn't wander. Post your address (and directions if necessary) beside the phone.
  • A standard home smoke detector isn't designed to be used in a stable. Its sensors quickly clog with barn dust, rendering it useless. Instead, use optical or heat-sensing smoke detectors which are designed for use in dusty locations.
  • If you operate a commercial stable, and are on a municipal water supply, consider putting in a sprinkler system. Horse fire safety expert Laurie Loveman has some excellent articles on the various considerations involved in setting up a sprinkler system. A sprinkler system is expensive, but check with your insurance agent - it may reduce your monthly premium.

Spice It Up

Countries such as India are largely vegetarian due to their religious beliefs. Yet India has one of the most exquisite and delicious range of foods in the world. From mild and creamy kormas to knock-your-socks-off madras, their curries offer a wide variety of meal options to suit any palate. The style of cooking varies from region to region, with some cultures preferring fried food with a high oil or butter content while others lean towards more tomato based recipes.

While lamb and chicken dishes may have been popularized in Indian restaurants and frozen meals around the world, the majority of traditional dishes in India do not contain any meat, providing an abundance of interesting recipes for vegetarians.

The key to Indian cooking lies in their use of spices such as cumin, turmeric, ginger, garlic, coriander, chili and cardamom. These spices are often blended into unique combinations that then form the basis of a particular style of dish, for example ‘garam masala.’ While these pre-prepared spice combinations are often available in any international aisle of your local food store, mixing your own blend is part of the adventure of exploring this cuisine, and key to finding the perfect balance for your own tastes.

Another great thing about Indian food is that there are plenty of side dishes that can be served along side a curry or as a meal by themselves.

Some top favorites are:

  • Dhal Soup – a lentil broth is spiced up with coriander, mustard seeds, ginger and other spices.
  • Palaak Aloo – often served as a side dish, this hearty blend of spinach and potatoes makes a filling lunch or snack.
  • Onion Bajees – grated onions are bound together with a paste made of chickpea flour and spices and then deep fried for a very more-ish snack.
  • Chana Masala – chickpeas in a rich and tangy tomato sauce with ginger, chili, and coriander.
  • Paneer Pakora – paneer is an Indian type of renett-free white cheese made by curdling milk with lemon juice. Small balls of the cheese are coated in a seasoned batter and deep fried in vegetable or ground nut oil to make Pakora.
  • Poppadums – the Indian equivalent of the Mexican tortilla, these thin wheat pancakes are fried until crisp and normally eaten with a trio of accompaniments: mango chutney, spiced onions and ‘raita’ (cucumber and yoghurt dip).

Indian vegetarian dishes are also extremely affordable and versatile, and as long as you have a basic stock of some key spices you will find you can create a delicious feast out of whatever ingredients you have to hand.

Angela Neal

help on car to buy

Hi: For the last 35+ years ,I have been driving caddie trading every 2yrs. for business use. Now after two open heart operations I had to stop working..I want to buy a smaller car that will last 5+ years or so rides real good little up keep. What should I looking at:maybe Alavon,300M,Linc.LS,BMW3series,VolvoS80.I am 67+ alone and do not need a big,big car.Will you advise me what kind of cars to look at.What you like the best

Recipe

HELP! My father-in-law turns 80 on Tuesday and has asked for a pinapple upside down cake. He is a diabetic. Does anyone have a recipe that will accomodate?

Everybody Loves Pac-Man

Pac-Man was an absolute phenomenon across the world. It was first released in 1980 by Namco in Japan and Midway licensed it for distribution in the US. Pac-Man was universally popular and transcended traditional gender barriers attracting an audience of female and male gamers of all ages. The game is quite possibly the most famous arcade release of all time and it has firmly established itself as an icon of popular culture.

 

Pac-Man featured a new style of game-play altogether casting the player in the role of a yellow circle with a big mouth and challenging them to navigate through a series of maze like levels eating up all the dots. Pac-Man is pursued by four ghosts in different colours who chase him through the maze and by eating one of the four larger dots in each corner of the map the player can supercharge Pac-Man and turn the tables to gobble down the ghosts. Periodically fruit appears in the centre of the map which the player can eat for bonus scores. In theory the game has no end and simply speeds up with each passing level until the player runs out of lives.

 

The game was developed by Toru Iwatani and took around a year and a half to design and develop. He had no experience of developing games when he joined Namco and was actually keen to work on pinball games but the company lacked a pinball division so they put him to work on an arcade title instead. He first produced a video game version based on pinball but when he began work on Pac-Man he aimed to make something which would appeal to all gamers. He wanted to create a game which was different to the popular titles of the day, which were mostly shooters like Space Invaders. The name of the character came from the Japanese slang word for the movement your mouth makes when you eat, paku paku. Toru was given a small team to help realise his vision and thanks to advances in the technology he was able to produce the game in colour.

 

The initial release in Japan was less than stellar and the game continued to be outsold by Space Invaders but when Midway picked it up for US release the popularity surprised everyone and it went on to be the biggest selling arcade title ever in America. Midway redesigned the cabinet and changed the name from Puck Man to Pac-Man. They sold over 100,000 games in the first year alone.

 

Pac-Man was also one of the first games to spawn a huge range of merchandising and many clones and sequels followed the original release. Pac-Man himself was soon one of the most recognisable video game characters around and his likeness graced everything from lunchboxes to t-shirts. The game also inspired a cartoon series and even a successful song.

 

The enduring appeal of Pac-Man is not hard to explain and in the violent world of videogames he stood out as a peaceful alternative with an innocently fun aim. The game-play remains deeply addictive and there are loads of free playable online versions. Namco have even released replica cabinets of the original which you can buy for your home.

new bike

hey i need a 125 honda or yam. dirt bike. if you think i am a boy well you got it wrong i am a girl stacie

Joe Biden Commemorative Plate

Thursday, December 11th 7:35am Dear Diary, After google-ing my name, as I like to do from time to time, I discovered that someone has recently come out with a Joe Biden Commemorative Plate. On first glance, this seemed like a great idea. Until I watched the video… It’s an outrage! The Joe Biden Commemorative Plate almost seemed like the creators are making a mockery of me. I’m sure that I have fans out there, but who would buy that plate? It almost seemed like they were belittling the role that I played in getting a Democratic Administration back in the White House. To start, I disliked the way the narrator said, “Jooooe Biiiiiden.” Not to mention, he was a little too happy about my “clean hair and articulate teeth.” (What are “articulate teeth” anyway?!) And when he finally brought up how I was in the shadow of history, he was basically saying that I’m just a little paint and the real deal is Barack Obama. Seems like they’re really belittling my role, especially when the seemed almost make fun of my achievements, and my commute to and from Delaware. Well, to whoever created that plate – I hope nobody buys it. Maybe it’s a joke, maybe it’s not. But regardless, that kind of mocking doesn’t deserve a profit. Oops, gotta put the pen down… I think Jill wants to discuss the plate. Well, according to Jill, the plate really was a joke. She said not to take it too harshly, but I’m upset! Who would create such am abhorrent thing, dismissing my contributions to the campaing, and society as a whole! And it’s the holiday season! People are looking for gifts to buy, and go figure – they’re probably just happening on this item as I did. Well, don’t buy that plate. There’s no reason to reward cruelty. Until next time, Joe the Veep

Shady Political Dealings

Thursday, December 11th 9:40pm

Dear Diary, Things have been pretty tense around the Obama household lately. After the media came out with all the information about the Illinois Governor, Rod Blagojevich, Barack has been very upset. Of course, I have to wonder how much Barack knew about that to begin with, but a lot of it was out of his control. After all, Blagojevich was involved with some shady dealings before this, evident by the fact that he was already being wiretapped before he tried to sell Barack’s Senate seat. Even still, it certainly doesn’t look good on the Obama Administration to even be remotely connected to this crime, and Barack’s become really upset about this. He keeps talking about how he’s been trying to distance himself from Blagojevich, calling him corrupt even before these dealings. Of course, everyone in Illinois knows that Chicago politics are corrupt. It’s true that 4 out of the past 7 governors have ended up in prison. Barack’s been lucky to have been able to rise above it for so long. Of course, I would not have put up with anything he may have tried. I’d like to think of that as a deterrent. But when it all comes down to it, Barack is a good man, and I can see how frustrated he is to have a scandal connected to his presidency before even assuming office. I guess the best thing that all of us can do is to stay out of trouble. Not that the Obamas will have a hard time with that. We just have to count on the Administration (and the rest of the Democrats) to help us maintain a good reputation. Yours always, Michelle

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